Tony X – Page 2 – Oncopeutic

BioNTech aims to develop mRNA-based malaria vaccine

General view shows the laboratories of BioNTech at their COVID-19 vaccine production facility as the spread of the coronavirus disease (COVID-19) continues, in Marburg, Germany, March 27, 2021. REUTERS/Kai Pfaffenbach/File Photo Plans to start clinical trial by end of 2022 Malaria kills more than 400,000 people per year BioNTech explores vaccine production in Africa BERLIN,…

Could Covid vaccine be taken as a pill?

By Maddy Savage BBC News, Stockholm Could this be how we take Covid vaccines in the future? Right now, protection against Covid-19 comes via an injection. But in future, those vaccines could come from inhalers or even pills. In a white, airy laboratory in Medicon Village, one of southern Sweden’s largest science parks, chemist Ingemo…

How protein-based COVID vaccines could change the pandemic

Jabs from Novavax and other biotech firms are coming. Scientists say they have a lot to offer. Elie Dolgin A participant in Novavax’s phase III trial receives a jab in early 2021.Credit: Kenny Holston/The New York Times/eyevine Pamela Sherry is eager to become immunized against COVID-19. But she has put off getting a jab. “I…

NEW PHASE 3 ANALYSES SHOW THAT A SINGLE DOSE OF REGEN-COV® (CASIRIVIMAB AND IMDEVIMAB) PROVIDES LONG-TERM PROTECTION AGAINST COVID-19

TARRYTOWN, N.Y., Nov. 8, 2021 /PRNewswire/ — Single dose of REGEN-COV (1,200 mg subcutaneous) reduced the risk of COVID-19 by 81.6% during the pre-specified follow-up period (months 2-8), maintaining the 81.4% risk reduction previously reported during month 1 During the 8-month assessment period there were 0 hospitalizations for COVID-19 in the REGEN-COV group and 6 in the…

MANUFACTURING Regeneron looks to inject another $330M into long-running manufacturing expansion plan: report

By Fraiser Kansteiner With COVID-19 boosting the company’s profile in a big way, Regeneron is returning to a long-running expansion with plans to inject some fresh cash into the project. Regeneron has designs on a $480 million manufacturing upgrade at its home base in Tarrytown, New York, Westfair Online reports, citing company talks with Westchester County’s Industrial Development Agency (IDA). Way back…

Targeted drug delivery for cancer therapy: the other side of antibodies

Michael A Firer & Gary Gellerman Abstract Therapeutic monoclonal antibody (TMA) based therapies for cancer have advanced significantly over the past two decades both in their molecular sophistication and clinical efficacy. Initial development efforts focused mainly on humanizing the antibody protein to overcome problems of immunogenicity and on expanding of the target antigen repertoire. In parallel…

Better fat bubbles could power a new generation of mRNA vaccines

New lipid delivery systems aim to improve potency and reduce side effects JOHANES CHRISTO/NURPHOTO BY ELIE DOLGIN As any dietician will tell you, some fats are good—and that is surely true of the little fatty balls found in two of the world’s most widely used COVID-19 vaccines. Known as lipid nanoparticles (LNPs), these…

The mRNA-LNP platform’s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory

SoniaNdeupen12ZhenQin12SonyaJacobsen1AurélieBouteau1HenriEstanbouli1Botond Z.Igyártó13 1 Department of Microbiology and Immunology, Thomas Jefferson University, Philadelphia 19107 PA, USA Received 10 May 2021, Revised 3 September 2021, Accepted 17 November 2021, Available online 20 November 2021, Version of Record 3 December 2021. Highlights •Lipid nanoparticles (LNPs) used for preclinical studies are highly inflammatory •The LNPs activate multiple inflammatory pathways…

Lipid Nanoparticles kill 80 percent of mice in PubMed Study

by Justus R. Hope, MD In 1989, Dr. Robert Malone invented the platform technology that allowed mRNA to transfer into mammalian cells. https://www.pnas.org/content/pnas/86/16/6077.full.pdf https://www.thedesertreview.com/opinion/columnists/humanitys-whistleblower-dr-robert-malone-sounds-the-alarm/article_e9c05e86-6ccf-11ec-9417-bbc21429de9c.html Dr. Malone’s invention stabilized nucleic acid by packaging it in a liposome with a positive charge. A liposome is a lipid sac that can carry drugs or other substances like mRNA…